Min Qiu1,
Zhimin Shangguan2,
Hao Zhang3 
For correspondence:- Hao Zhang Email: zhanghao_hww@163.com Tel:+862133189900
Accepted: 27 September 2020 Published: 30 October 2020
Citation:
Qiu M, Shangguan Z, Zhang H.
Downregulation of miR-451a in plasma may promote prothrombin ex
© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate F2 and miR-451a levels in gestational diabetes mellitus (GDM) patients, evaluate the potential role of miR-451a in GDM, and to explore its possible downstream targets.
Methods: Thromboelastography (TEG) analysis was conducted to analyze coagulation differences between the GDM and control groups. Quantitative polymerase chain reaction (qPCR) and immunoblot were performed to analyze miR-451a and F2 levels after exposure to high glucose and miR-451a mimics or an miR-451a inhibitor. Luciferase assay was used to explore the potential regulatory mechanism.
Results: Enhancement of the patients' blood coagulation ability and down-regulated miR-451a ex
Conclusion: MiR-451a may serve as a promising marker for hypercoagulable state GDM patients
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